|
KMID : 1123920200340010001
|
|
Korean Journal of Oriental Physiology and Pathology
2020 Volume.34 No. 1 p.1 ~ p.6
|
|
|
Arctii Lappa Fructus Extract Induces Lipogenesis through SREBP-1 Activation of Sebocytes
|
|
In Myung-Hee
Mun Yeun-Ja
Woo Won-Hong
|
|
|
Abstract
|
|
|
|
Arctii Lappa Fructus has the numerous health benefits, including antioxidant, anti-inflammatory, and anti-carcinogenic properties. Skin lipids are one of several factors that maintain epidermal barrier function. This study was to explore the lipogenic effect by ethanol extract of Arctii Lappa Fructus (EAF) in sebocytes. First, it was confirmed that EAF exhibited high antioxidant activity and collagenase activity inhibition. We found that cholesterol and triglyceride levels of cells by EAF were increased significantly in a dose-dependent manner. Moreover, EAF increased the expression of transcription factor sterol regulatory element-binding protein-1 (SREBP-1) in the cells. These results suggest that EAF induces lipogenesis in cells through the activation of SREBP-1.
|
|
|
KEYWORD
|
|
|
Arctii Lappa Fructus, Cholesterol, Triglyceride, SREBP-1, Sebocyte
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|